Automating the generation and analysis of 3D cell cultures in Matrigel®

Researchers are turning to three-dimensional (3D) cell culture as a way to increase the biological relevance of their disease models and predictive value of drug studies1. These 3D models typically increase the level of cell-cell interaction and reduce or eliminate the dominant cell-plastic interaction seen in standard monolayer cultures. There are a number of ways of generating 3D cell cultures, each with unique advantages and challenges, many of which automation can help overcome.